Cervical carcinoma (CC) is the fourth most common malignancy among women. Screening with Papanicolau smear is linked to a reduction in CC incidence rates when screening programs have been developed. However, this technique has several limitations, including moderate sensitivity rates for detection of cervical preneoplastic HPV-related lesions. In this real-world study, we proposed to evaluate
Of those, 5598 (93·5%) attended and completed the initial colposcopy with a median time of 1·8 months (IQR 1·2–2·8) after recruitment. 4762 (85·1%) of 5598 women with an initial normal colposcopy or with negative or CIN1 histology (less than CIN2 or inadequate biopsy) were recalled at 18 months for a second HPV test and referred to
Previous literature has indicated that TTMV-HPV DNA can be detected in plasma several years before diagnosis; therefore, we defined a true positive test as any positive TTMV-HPV DNA test leading up to a pathologically confirmed recurrence. 15 We considered a negative TTMV-HPV DNA test measured within 3 months of a pathologically confirmed
Cytology-based cervical cancer screening programs have been difficult to implement and scale up in developing countries. Thus, the World Health Organization recommends a ‘see and treat’ approach by way of hr-HPV testing and visual inspection. We aimed to evaluate concurrent HPV DNA testing and visual inspection in a real-world low-resource setting by comparing the detection rates of
HPV testing has been proposed as an adjunctive test to improve the sensitivity and negative predictive value of the Pap smear. At a reduced cost, HPV testing could improve sensitivity with only
Altogether, 1337 pieces of HPV-related DNA were detected, representing 23 new types of HPV, 10 established types of HPV and two known HPV DNA sequences. This new style of testing has highlighted
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hpv dna test negative means
